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David McCandlish
Friday, September 15, 2017, 02:30pm - 03:30pm
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Contact Host: Tom MacCarthy
Assistant Professor
Simons Center for Quantitative Biology
Cold Spring Harbor Lab
 
Modeling and understanding complex sequence-function relationships
 
Advances in high-throughput genetics now allow the effects of thousands of mutations to be measured simulateneously.  How can we understand the complex patterns of genetic interaction revealed by these assays?  I will showcase several computational tools to address this problem with applications to protein stability and function, transcription factor binding sites, RNA folding, and molecular evolution.
Location Laufer Center Lecture Hall 101