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Claus Wilke
Friday, October 19, 2018, 02:30pm - 03:30pm
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Contact Ken Dill
Department Chair, Professor
Department of Integrative Biology
University of Texas at Austin
 
Structural and Functional Constraints on Protein Evolution

Proteins evolve under constraints determined by their structural and functional properties. These constraints are visible in co-variation among sites and in increase sequence conversation at sties in the protein core, near active sites in enzymes, or at sties involved in protein-protein interfaces. I will discuss first the relative importance of these structural and functional constraints on sequence conservation. Then, I will discuss how co-variation among sites can be used to infer a protein’s contact matrix, and how the accuracy of the inference depends critically on the definition of a medium-residue contact. Finally, I will discuss how, in the context of duplicated genes, selective constraints can percolate through protein-protein interaction networks, such that a duplicated gene imposes significant selection pressure on its non-duplicated partner.

 

 

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Location Laufer Center Lecture Hall 101
Refreshments following lecture in Laufer Hub 11