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Christine Vogel
Friday, September 12, 2014, 02:30pm - 03:30pm
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Contact Host: Markus Seeliger
Christine Vogel
Assistant Professor
Department of Biology
Center for Genomics and Systems Biology
New York University

 

Yeast ubiquitinomics -- cellular signaling during oxidative stress

Protein ubiquitination is an important modification with a variety of cellular functions. These functions are determined by the lysine through which polyubiquitin chains are linked. While K48 polyubiquitination is most abundant and well-studied, much less is known about K63 chains that occur frequently in the cell. Ongoing studies in our lab investigate the roles of both K48 and K63 polyubiquitination. Using a combination of large-scale methods and targeted screens we identified a new role for K63 polyubiquitination under peroxide stress. We identified both the ubiquitinating and deubiquitinating enzymes, as well as a set of target proteins which suggest a role of K63 polyubiquitination in translation regulation.

 

Location Laufer Center Lecture Hall 101