Physical & Quantitative Biology, CHE/PHY 558
Fall 2014 / MWF 10 – 11 AM in Laufer Center 101
Ken Dill, Course PI
Course goals: The central idea of this course is the free energy, the quantitative way we understand driving forces, i.e., the equilibria and rates in chemistry, physics and biology. We describe the underpinning components, the entropy and energy. We explore the microscopic interactions -- including hydrogen bonding, van der Waals, electrostatics and hydrophobic forces -- that explain physical and chemical mechanisms in biology and are the workhorse tools in computational drug discovery. We show how these basic ideas are applied: binding affinities are the basis for drug discovery; coupled binding is the basis for how biological machines convert energy and transduce signals; and polymer free energies are the basis for the folding of protein and RNA molecules.
Please login to get the links to the videos
MDF = Molecular Driving Forces, chapter numbers.
PP = Protein Principles, draft textbook.
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