Laufer Junior Fellows

jason1 Jason Wagoner is interested in the study of chemical/biological problems using the perspective and tools drawn from chemical physics and statistical mechanics. This includes the study of aqueous solvation and molecular assembly, as well as the development of new simulation techniques for the multiscale modeling of biomolecular systems. (Citations)



Postdoctoral Associates

bien Harold Bien. Balázsi lab
emilano Emiliano Brini. My research focuses on solvation thermodynamic. In particular I am interested in understanding how the environment of a chemical group affects its solvation properties and therefore its interaction with the rest of the system. On this path I am currently working on the development of a solvation model that can be used to run implicit solvent molecular dynamic simulation of complex object like protein and protein aggregates.
bhanita Bhanita Sharma. My research focuses on probing the protein aggregation and fibril formation using MELD simulation method. Protein aggregation involves self-assembly of normally soluble proteins into insoluble amyloid fibrils, which are linked to several diseases. I believe that the powerful approach of combined physics-based atomistic model with enhanced conformational sampling techniques can provide important insights into the early stages of protein aggregation and fibril formation, structural characteristics of protein fibrils and binding mode of amyloid inhibitors.
tamas Tamás Székely. I am interested in non-genetic variability, which enables genetically identical cells to have different properties (phenotypes). A cell's phenotype can change over time, and is influenced by its environment as well as the randomness of biochemical reactions inside the cell, as genes are translated into proteins. Cell populations can consist of multiple phenotypes, with different phenotypes surviving better in different environments. Phenotype switching allows cell populations as a whole to survive stressors and toxins that only some of their phenotypes can tolerate. In particular, combining both experiments and theory, I am working on understanding how phenotype switching itself evolves in different environmental conditions, and how this leads to a cell population with a particular set of phenotypes.