Combining genotypes and T cell receptor distributions to infer the genetic determinants of V(D)J recombination probabilities

Abstract: Receptor proteins on the surfaces of T cells are an essential component of the cell-mediated adaptive immune response. V(D)J recombination can generate repertoires of T cell receptors with remarkable diversity. This diversity is achieved through the stochastic joining of V, D, and J gene segments, removal of junctional nucleotides from selected gene segments, and insertion of non-template encoded nucleotides at the gene junctions. The extent to which an individual’s genetic background may bias these steps is not fully understood. In this talk, I will describe our work to identify genetic variants that influence T-cell receptor V(D)J recombination probabilities via a genome-wide association study. I will also give an update on our progress to place our results into a mechanistic context using model-based statistical inference on high-throughput T cell repertoire data.

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Tom MacCarthy, host

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Meeting ID: 956 1591 2198, Passcode: laufer