Department of Cell Biology
Harvard Medical School
Unlocking the secrets of complex proteomes and molecular phenotypes
Proteins, as the essential functional molecules in nearly all biological processes, offer the direct cellular functional snapshot of biological systems and comprise most existing drug targets. Mass spectrometry (MS)-based proteomics has evolved into an essential tool, allowing for both qualitative and quantitative analyses. However, despite decades-long effort, routine full-proteome interrogation of the biological pathways remains challenging due to several limitations of technology, including suboptimal sensitivity, accuracy, and throughput.
My research focuses on leveraging chemistry, bioinformatics, and biology to build novel high-performance sample multiplexing-based proteomics technologies and ultimately to address grand challenges in biomedical research and develop therapeutics. In this talk, I will present an intelligent platform for multiplexed proteomics that integrates millisecond informatics for real-time decision making, and thereby enabling next-generation discovery and hypothesis-driven protein research. I will demonstrate how I apply the technology innovations to investigate impacts of genetic variation on protein expression and lipid metabolism using a cohort of 480 diversity outbred mice. The study leads to the discovery of single nucleotide polymorphisms (SNPs) that cause differential protein expression. By integrating genomics and lipidomics, it further identifies previously unknown lipid species and reveals proteins responsible for their metabolism
Host: Gabor Balazsi
This will be a hybrid seminar but we hope that you will join in person.
In person: Laufer Lecture Hall 101
Refreshments following the seminar in room 110