Department of Chemical and Biomedical Engineering
Simulations of biomolecular assembly processes at interfaces
Although biomolecular folding, binding and assembly are usually conceived of as occurring in a bulk aqueous solution, there are numerous instances of such processes occurring near interfaces within cells. Examples of these interfaces include very large macromolecules, membranes bounding intracellular compartments and the cell membrane itself. Interfacial behavior of biomolecules is also important in several technological applications such as DNA-based nanomaterials, biosensors, and microarrays. In this talk, I will discuss several ongoing research problems in my group that illustrate rich behavior exhibited by biomolecules (protein, DNA) at interfaces.